Actinobaculum schaalii, a common uropathogen in elderly patients, Denmark.
|Title||Actinobaculum schaalii, a common uropathogen in elderly patients, Denmark.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Authors||Bank, S, Jensen, A, Hansen, TM, Søby, KM, Prag, J|
|Journal||Emerg Infect Dis|
|Date Published||2010 Jan|
|Keywords||Actinomycetaceae, Actinomycetales Infections, Age Factors, Aged, Aged, 80 and over, Denmark, Female, Humans, Male, Middle Aged, Phylogeny, Polymerase Chain Reaction, Urinary Tract Infections, Urine|
Actinobaculum schaalii can cause urinary tract infections and septicemia but is difficult to identify by cultivation. To obtain a fast diagnosis and identify A. schaalii, we developed a TaqMan real-time quantitative PCR. Routine urine samples were obtained from 177 hospitalized patients and 75 outpatients in Viborg County, Denmark, in 2008-2009. The PCR detected A. schaalii in 22% of samples from patients >60 years of age. This assay showed that A. schaalii is more common than implied by routine cultivation. In 90% of PCR-positive urine samples, other common uropathogens were identified. This finding suggests that A. schaalii is a common, undetected, bacterial pathogen. Our results suggest that A. schaalii may be a more common pathogen than previously thought, especially in patients with unexplained chronic urinary tract infections, who are often treated with trimethoprim or ciprofloxacin, to which A. schaalii is resistant.
|Alternate Journal||Emerg Infect Dis|
|PubMed Central ID||PMC2874361|