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Analysis of Genotypes Amongst Jordanians' Dental Plaque Samples.

TitleAnalysis of Genotypes Amongst Jordanians' Dental Plaque Samples.
Publication TypeJournal Article
Year of Publication2018
AuthorsAbu-Lubad, M, Alzoubi, H, Jarajreh, D'a, Sawalqa, AAl, Br├╝ggemann, H, Albataineh, E, Aqel, A, Al-Zeer, M
JournalGastroenterology Res
Date Published2018 Feb

Background: () infection has been associated with gastritis, gastric ulcer, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The prevalence of virulence genes have been studied in different populations and from different sources of samples but their prevalence has not been studied in dental plaque in Jordanian people; therefore, the aim of this study was to determine the genotypes of isolated from dental plaque samples.Methods: Dental plaque samples were collected from 60 Jordanian volunteers. The genotypes of virulence genes including the cytotoxin-associated gene A () and the vacuolating toxin () were determined using polymerase chain reaction (PCR).Results: The gene was detected in 14 (23.3%) samples, while was detected in all volunteers enrolled in this study (100%). The most prevalent alleles were m2 and s1 in 54 (90%) and 55 (91.7%) of volunteers, respectively. Compared to the other combinations including the most virulent genotype s1/m1 which was detected in 11 (18.2%) of volunteers, the most prevalent allelic combinations were s1/m2 and s2/m2 in 56 (93.3%) and 27 (45%) of volunteers, respectively.Conclusions: These results indicate a significant carriage of virulent strains among Jordanian people in their dental plaques, which increases the possible transmission of these strains among them. In addition, the studying of the genotypic pattern of virulence genes in the dental plaque could represent an essential tool for infection prevention and predicting the severity and prognosis of gastric infection.

Alternate JournalGastroenterology Res
PubMed ID29511406
PubMed Central IDPMC5827902