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Finegoldia magna Isolated from Orthopedic Joint Implant-Associated Infections.

TitleFinegoldia magna Isolated from Orthopedic Joint Implant-Associated Infections.
Publication TypeJournal Article
Year of Publication2017
AuthorsSöderquist, B, Björklund, S, Hellmark, B, Jensen, A, Brüggemann, H
JournalJ Clin Microbiol
Volume55
Issue11
Pagination3283-3291
Date Published2017 11
ISSN1098-660X
KeywordsAdult, Aged, Aged, 80 and over, Animals, Anti-Bacterial Agents, Debridement, Disk Diffusion Antimicrobial Tests, Female, Firmicutes, Gram-Positive Bacterial Infections, Humans, Male, Middle Aged, Molecular Epidemiology, Molecular Typing, Osteoarthritis, Phylogeny, Prosthesis-Related Infections, Retrospective Studies, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Whole Genome Sequencing
Abstract

The anaerobic Gram-positive coccus is a rare cause of infections of bone and joints. The aim of this study was to describe the microbiological and clinical characteristics of orthopedic implant-associated infections caused by We retrospectively analyzed samples consisting of anaerobic Gram-positive cocci and samples already identified as from patients with orthopedic infections. The isolates found were determined to the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The antibiotic susceptibility pattern was determined by Etest. Whole-genome sequencing (WGS) was performed. Clinical data were extracted from each patient's journal. In nine patients, orthopedic joint implant-associated infections were identified as being caused by The isolates were susceptible to most of the antibiotics tested, with the exception of rifampin and moxifloxacin in a few cases. Five of the nine infections were monomicrobial. The most common antibiotic used to treat the infection was penicillin V, but five of the nine patients received a combination of antibiotics. Eight patients underwent surgical treatment, with extraction of the implant performed in seven cases and reimplantation in only two cases. The WGS showed a relatively small core genome, with 126,647 single nucleotide polymorphisms identified within the core genome. A phylogenomic analysis revealed that the isolates clustered into two distinct clades. Orthopedic implant-associated infections caused by are rare, but the bacteria are generally susceptible to antibiotics. Despite this, surgical treatment combined with long-term antibiotics is often necessary. The WGS analysis revealed a high heterogeneity and suggested the existence of at least two different species.

DOI10.1128/JCM.00866-17
Alternate JournalJ Clin Microbiol
PubMed ID28904182
PubMed Central IDPMC5654912