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Is IL-1β Further Evidence for the Role of in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris.

TitleIs IL-1β Further Evidence for the Role of in Degenerative Disc Disease? Lessons From the Study of the Inflammatory Skin Condition Acne Vulgaris.
Publication TypeJournal Article
Year of Publication2018
AuthorsSlaby, O, McDowell, A, Brüggemann, H, Raz, A, Demir-Deviren, S, Freemont, T, Lambert, P, Capoor, MN
JournalFront Cell Infect Microbiol
Volume8
Pagination272
Date Published2018
ISSN2235-2988
KeywordsDiscitis, Gram-Positive Bacterial Infections, Humans, Interleukin-1beta, Intervertebral Disc Degeneration, Models, Biological, Propionibacterium acnes
Abstract

The pathogenesis of degenerative disc disease is a complex and multifactorial process in which genetics, mechanical trauma, altered loading and nutrition present significant etiological factors. Infection of the intervertebral disc with the anaerobic bacterium is now also emerging as a potentially new etiological factor. This human commensal bacterium is well known for its long association with the inflammatory skin condition acne vulgaris. A key component of inflammatory responses to in acne appears to be interleukin (IL)-1β. Similarly, in degenerative disc disease (DDD) there is compelling evidence for the fundamental roles of IL-1β in its pathology. We therefore propose that involvement in DDD is biologically very plausible, and that IL-1β is the key inflammatory mechanism driving the host response to infection. Since there is a solid theoretical basis for this phenomenon, we further propose that the relationship between infection and DDD is causal.

DOI10.3389/fcimb.2018.00272
Alternate JournalFront Cell Infect Microbiol
PubMed ID30155445
PubMed Central IDPMC6103242
Grant ListMR/N00583X/1 / / Medical Research Council / United Kingdom