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The impact of Cymbopogon martinii essential oil on Cutibacterium (formerly Propionibacterium) acnes strains and its interaction with keratinocytes.

TitleThe impact of Cymbopogon martinii essential oil on Cutibacterium (formerly Propionibacterium) acnes strains and its interaction with keratinocytes.
Publication TypeJournal Article
Year of Publication2018
AuthorsAndrade, BFernanda M, Barbosa, LNunes, Alves, FCristina B, Marques, AFlávia Pe, Albano, M, Rall, VLúcia Mor, Brüggemann, H, Júnior, AFernandes
JournalJ Pharm Pharmacol
Volume70
Issue12
Pagination1688-1699
Date Published2018 Dec
ISSN2042-7158
KeywordsAcyclic Monoterpenes, Cymbopogon, Dose-Response Relationship, Drug, Humans, Keratinocytes, Microbial Sensitivity Tests, Oils, Volatile, Propionibacterium acnes, Skin, Terpenes
Abstract

OBJECTIVES: The human skin microbiota is mainly composed of bacteria belonging to the genera Staphylococcus, Cutibacterium, Micrococcus and Corynebacterium, but on the skin of the face and back, ca. 50% of the total microbiota is represented by the bacterium Cutibacterium acnes. The aim of this research was to evaluate the impact of C. martini EO and its major compound, geraniol, on C. acnes.METHODS: The minimum inhibitory concentration against C. acnes strains, phenotypic changes and responses of the proteome was determined. In addition, was assessed the effect of compounds in RNA-binding assay, on C. acnes-exposed keratinocytes and on the C. acnes type distribution on shoulder skin.KEY FINDINGS: The range of the MIC was 0.7 to 1.6 mg/ml for the three main C. acnes types. There were no cytotoxic effects of compounds in the absence or presence of C. acnes; after 7 days of exposure to C. martini EO, we could not detect a major shift of the C. acnes types on shoulder skin that was found to be dominated by C. acnes strains of types II and IA2.CONCLUSIONS: Our work gives novel insight into the skin microbiota-interacting properties of C. martini EO.

DOI10.1111/jphp.13011
Alternate JournalJ Pharm Pharmacol
PubMed ID30277563
Grant List2014/24094-7 / / São Paulo Research Foundation-FAPESP /
2015/12906-0 / / São Paulo Research Foundation-FAPESP /