Error message

Deprecated function: implode() [function.implode]: Passing glue string after array is deprecated. Swap the parameters in drupal_get_feeds() (line 394 of /var/www/

Multilocus Sequence Typing (MLST) and Phylogenetic Analysis of Propionibacterium acnes.

TitleMultilocus Sequence Typing (MLST) and Phylogenetic Analysis of Propionibacterium acnes.
Publication TypeJournal Article
Year of Publication2011
AuthorsKilian, M, Scholz, C, Lomholt, HB
JournalJ Clin Microbiol
Date Published2011 Dec 28

Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris and in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer. As the species includes evolutionary lineages with distinct association with health and disease, there is a need for a high-resolution typing scheme. Recently, two MLST schemes were reported, one based on nine and one based on seven housekeeping genes. In the present study, the two schemes were compared with reference to a phylogenetic tree based on 78 P. acnes genomes and their gene contents. Further support for a basically clonal population structure of P. acnes and a scenario of global spread of epidemic clones of P. acnes was obtained. Compared with the Belfast scheme, the Aarhus MLST scheme ( based on nine genes offers significantly enhanced resolution and phylogenetic inferences more concordant with analyses based on a comprehensive sampling of the entire genomes, their gene contents, and their putative pathogenic potential.

Alternate JournalJ. Clin. Microbiol.
PubMed ID22205788