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: An Overlooked Human Skin Colonizer.

Title: An Overlooked Human Skin Colonizer.
Publication TypeJournal Article
Year of Publication2020
AuthorsAhle, CM, Stødkilde, K, Afshar, M, Poehlein, A, Ogilvie, LA, Söderquist, B, Hüpeden, J, Brüggemann, H
JournalMicroorganisms
Volume8
Issue8
Date Published2020 Jul 23
ISSN2076-2607
Abstract

Coagulase-negative staphylococcal species constitute an important part of the human skin microbiota. In particular, facultative anaerobic species such as and can be found on the skin of virtually every human being. Here, we applied a culture-independent amplicon sequencing approach to identify staphylococcal species on the skin of healthy human individuals. While and were found as primary residents of back skin, surprisingly, the third most abundant member was , a relatively unstudied species. A search of skin metagenomic datasets detected sequences identical to the genome of in diverse skin sites, including the back, forehead, and elbow pit. Although described as a slow-growing anaerobic species, a re-evaluation of its growth behavior showed that can grow under oxic conditions, and, in particular, in a CO-rich atmosphere. We argue here that was largely overlooked in previous culture-dependent and -independent studies, due to its requirement for fastidious growth conditions and the lack of reference genome sequences, respectively. Future studies are needed to unravel the microbiology and host-interacting properties of and its role as a prevalent skin colonizer.

DOI10.3390/microorganisms8081105
Alternate JournalMicroorganisms
PubMed ID32718033
PubMed Central IDPMC7465461
Grant ListNNF18OC0053172 / / Novo Nordisk /