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Skin microbiome modulation induced by probiotic solutions.

TitleSkin microbiome modulation induced by probiotic solutions.
Publication TypeJournal Article
Year of Publication2019
AuthorsPaetzold, B, Willis, JR, de Lima, JPereira, Knödlseder, N, Brüggemann, H, Quist, SR, Gabaldón, T, Güell, M
JournalMicrobiome
Volume7
Issue1
Pagination95
Date Published2019 06 24
ISSN2049-2618
KeywordsAdult, Bacteria, Bacterial Load, Female, Healthy Volunteers, Humans, Male, Microbiota, Probiotics, Propionibacteriaceae, Skin, Skin Diseases, Young Adult
Abstract

BACKGROUND: The skin is colonized by a large number of microorganisms, most of which are beneficial or harmless. However, disease states of skin have specific microbiome compositions that are different from those of healthy skin. Gut microbiome modulation through fecal transplant has been proven as a valid therapeutic strategy in diseases such as Clostridium difficile infections. Therefore, techniques to modulate the skin microbiome composition may become an interesting therapeutic option in diseases affecting the skin such as psoriasis or acne vulgaris.METHODS: Here, we have used mixtures of different skin microbiome components to alter the composition of recipient skin microbiomes.RESULTS: We show that after sequential applications of a donor microbiome, the recipient microbiome becomes more similar to the donor. After intervention, an initial week-long phase is characterized by the dominance of donor strains. The level of engraftment depends on the composition of the recipient and donor microbiomes, and the applied bacterial load. We observed higher engraftment using a multi-strain donor solution with recipient skin rich in Cutibacterium acnes subtype H1 and Leifsonia.CONCLUSIONS: We have demonstrated the use of living bacteria to modulate skin microbiome composition.

DOI10.1186/s40168-019-0709-3
Alternate JournalMicrobiome
PubMed ID31234928
PubMed Central IDPMC6591853
Grant ListG02/2015 / / German government /
Chile Startup Program 2014 / / Ministerio de Educación, Gobierno de Chile /
MINECO-RYC-2015-17734 / / Spanish Government /