The Human Microbiota in Heath and Disease

Recent years’ research has highlighted the importance of the human microbiota, i.e. the trillions of microorganisms that colonize different surfaces of our body. We are starting to understand how important this microbiota is, e.g. in terms of its impact on physiological functions and on shaping the immune system. Changes of the microbial composition can dispose for diseases, ranging from allergy and other inflammatory conditions to obesity and cancer. Our team focuses on microbiota-human host interactions in health and disease. The work includes:

- molecular mapping of complex microbiotas of the human superorganism

- population genetics and taxonomy of human-associated bacterial species, including pan-genomics of selected species

- host-bacterium interactions to study host signalling events

- bacterial interference on the human host and their consequences

One of our aims is to obtain improved information on the molecular details of host-bacterium interactions that may facilitate identification, prevention, and treatment of infectious diseases.